Furoic acid and derivatives as atypical dienes in Diels–Alder reactions

DISCOVERY OF NEW SELECTIVE DIELS-ALDER REACTIONS USING ETHYLENE: PRODUCTION OF PTA FROM HMF VIA OXIDATION ROUTE 5.1 New ethylene Diels-Alder-dehydration reactions using 5-methyl-2-furoic acid (MFA) and methyl 5-methyl-2-furoate (MMF) as dienes

Reactions of Carboxylic Acid Derivatives I

This is probably the single most important reaction of carboxylic acid derivatives. The overall transformation is defined by the following equation, and may be classified either as nucleophilic substitution at an acyl group or as acylation of a nucleophile. For certain nucleophilic reagents the reaction may assume other names as well. If Nuc-H is water the reaction is often called hydrolysis, i...

Novel Group of Imidazole Derivatives as Atypical Selective Cyclooxygenase-2 Inhibitors: Design, Synthesis and Biological Evaluation

In this study, a new series of 5-substituted 1-benzyl-2-(methylsulfonyl)-1-H-imidazolewith atypical structure-activity relationship was designed, synthesized, and biologicalevaluated as selective cyclooxygenase-2 inhibitors. Docking studies revealed that althoughthe pharmacophoric substitute of the compound 5b, methylsulfonyl group, has been directlyattached to the central ring, it is in the sa...

Novel Group of Imidazole Derivatives as Atypical Selective Cyclooxygenase-2 Inhibitors: Design, Synthesis and Biological Evaluation

In this study, a new series of 5-substituted 1-benzyl-2-(methylsulfonyl)-1-H-imidazolewith atypical structure-activity relationship was designed, synthesized, and biologicalevaluated as selective cyclooxygenase-2 inhibitors. Docking studies revealed that althoughthe pharmacophoric substitute of the compound 5b, methylsulfonyl group, has been directlyattached to the central ring, it is in the sa...

Chemoselective Reactions of (E)-1,3-Dienes: Cobalt-Mediated Isomerization to (Z)-1,3-Dienes and Reactions with Ethylene

GENERAL METHODS S4 SYNTHESIS OF SUBSTRATES S4-S6 Synthesis of (Z)and (E)-1-cyclohexyl-1,3-butadiene (8) Typical procedure for the synthesis of (Z)and (E)-1,3-dienes (Z)and (E)-1-Benzylbuta-1,3-diene (18) (Z)and (E)-1-(2-Furyl)-1,3-butadiene (21) (Z)and (E)-1-(4-Butyl-1-cyclohexyl)-1,3-butadiene (22) SYNTHESIS OF COBALT COMPLEXES S7 CHEMOSELECTIVE ASYMMETRIC HYDROVINYLATIONS S7 Asymmetric hydrov...